Endocrine Abstracts

IntroductionA biosimilar is a biological medicinal product that shows high similarity to another already approved medicine product containing biotechnology-derived protein as active substance. The similarity depends on the biosimilar development program that includes comparative studies of physical and chemical properties, in vitro pharmacodynamics, pharmacokinetics and pharmacodynamics in humans. Insulin aspart biphasic 30 is one of the most co...

The combination of thyroid and parathyroid carcinoma (PC) are extremely rare. We present a case with metastases of both tumors to the lymph nodes of the neck in a woman who received renal replacement therapy with long-term hemodialysis.Case reportIn 1984, when she was 24 years old, the patient began working at a nuclear power plant as a chemical water treatment operator. The total length of service was 25 years. In 2009 (at the age...

Traditionally, patients diagnosed with primary hyperparathyroidism present with mild hypercalcaemia and tend to be asymptomatic. Symptomatic patients tend to have severely high calcium and exhibit the classic ’bones, stones, abdominal moans and psychic groans.’ We present a case of a 92-year-old Caucasian gentleman presenting with recurrent falls, postural hypotension and trauma to head and shoulder. X-ray imaging showed small non-specific lucencies in the cervical a...

Background: Adrenal incidentalomas (AI), the finding of asymptomatic adrenal lesion on unrelated imaging, represent an increasing number of endocrine referrals. In 2022, we introduced a nurse-led pathway to manage AI.Aim: To assess the cost savings and patient experience of a telephone nurse-led AI service at Musgrove Park Hospital.Methods: Records for patients seen in the AI clini...

Background: Metastases to the sellar region are extremely rare tumours in surgical series. The reported incidence has recently increased with advances in neuroimaging. Survival of patients with metastatic cancer has improved due to progress in oncologic therapies and diagnostics. Patients with sellar metastases (SM) follow a variable disease course that is not well defined.Objective: The objective was to evaluate the clinical characteristics, surgical ap...

Background: It is well known that both genetic backgroup and lifestyle influence the development of ‘general’ obesity. However, the role of parental body mass index (BMI) on the development of obesity in long-term survivors of childhood-onset craniopharyngioma (CP) is not well understood. This study aimed to analyze the correlation of patients’ BMI at diagnosis, and last visit and parental BMI at CP diagnosis and further explored potential risk factors for obesi...

Background: Rathkes cleft cysts (RCC) are present in up to 20% of autopsy studies but only a minority necessitate surgical treatment1. Inflammation of the RCC wall may act a trigger for disease progression, resulting in development of clinical symptoms and prompting investigation and surgical management2,3. The significance of inflammation of RCC is thought to be three-fold: the development of classical symptoms including headache, visual disturbance or p...

Background: Graves’ disease in combination with thyroid nodules is more common in women. However, more than one in three patients has carcinoma. Unfortunately, thyroid cancer is most frequently detected accidentally after a thyroidectomy for Graves’ disease, despite the wide possibilities of modern diagnostic methods.Clinical case: A 55-year women complained of discomfort in the neck, sweating, irritability, palpitation. From anamnesis: in 20...

Heterozygous mutations in GNAS1, which encodes the Gαs protein involved in multiple signalling pathways, are classically associated with Albright’s Hereditary Osteodystrophy (AHO). GNAS1 is one of few genetic loci that undergo allelic-specific methylation resulting in the parent-specific expression of at least four different transcripts. The classic constellation of phenotypic features includes short stature, round face, brachydactyly, obesity, dental hypopl...

Purpose: Androgens promote early follicular development and granulosa cell proliferation by augmenting follicle-stimulating hormone (FSH) receptor expression in granulosa cells. Several retrospective studies have evaluated the association between basal androgen concentrations and follicular development in women undergoing ovarian stimulation for in vitro fertilization (IVF) with conflicting results. The aim of this study was to investigate whether basal androgen concentrations...